The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

Key Points

• To explore how inhibiting metabolic pathways influences the occurrence of adverse drug reactions (ADRs).
• Applied a backward selection approach to identify inhibited pathways.
• Analyzed data correlating metabolism-inhibiting drugs with ADR occurrence.
• Proposed further validation in an additional dataset.
• High burden of pathway inhibition is linked to increased ADR occurrence.
• Identified key pathways that contribute to ADRs in the analyzed dataset.