ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disorder that has a high worldwide prevalence and carries substantial psychosocial and financial burden. As such, the prevention of AD is an important area of research. In this review, we provide an update synthesizing relevant clinical trials published from January 2020 through July 2025. Based on the available evidence, moisturizers and probiotics in infancy appear to have the most benefit in the primary prevention of AD compared to other interventions. However, relatively small effects, varying results, and heterogeneity of trial design make firm conclusions impossible at this time.
Kiszluk et al. (2026) studied this question.