Increasing physical activity to ≥500 MET-min/wk after diagnosis of type 2 diabetes mellitus reduced incident depression risk by 23-25% compared to inactivity.
Cohort (n=254,619)
Yes
Does increasing physical activity reduce incident depression in patients with newly diagnosed type 2 diabetes mellitus?
Increasing physical activity after a new diagnosis of type 2 diabetes mellitus is associated with a significantly reduced risk of developing incident depression.
Effect estimate: HR 0.75 for ≥1,000 MET-min/wk increase; HR 0.77 for 500–999 MET-min/wk increase (95% CI 95% CI 0.57 to 0.997 for ≥1,000 MET-min/wk; 0.62 to 0.95 for 500–999 MET-min/wk)
Absolute Event Rate: 10.92% vs 16.84%
p-value: p=0.0056
Changes in physical activity levels before and after a new diagnosis of T2DM significantly influence the risk of developing depression, with increased activity reducing the risk and decreased activity elevating the risk. This finding underscores the importance of encouraging physical activity to support mental health in patients with newly diagnosed T2DM.
Park et al. (Mon,) conducted a cohort in newly diagnosed type 2 diabetes mellitus without prior depression (n=254,619). increase in physical activity after diagnosis measured in MET-min/wk vs. no increase or decreased physical activity was evaluated on incident depression after new diagnosis of T2DM diagnosed by ICD-10 codes F32, F33 plus antidepressant use with ≥2 hospital visits (HR 0.75 for ≥1,000 MET-min/wk increase; HR 0.77 for 500–999 MET-min/wk increase, 95% CI 95% CI 0.57 to 0.997 for ≥1,000 MET-min/wk; 0.62 to 0.95 for 500–999 MET-min/wk, p=0.0056). Increasing physical activity to ≥500 MET-min/wk after diagnosis of type 2 diabetes mellitus reduced incident depression risk by 23-25% compared to inactivity.