Stability, in vitro release, and pharmacokinetic evaluation of standardized crude extracts, isolated compounds, and their nano-liposomes derived from Syzygium campanulatum Korth using Sprague-Dawley rats.

Key Points

• This research aims to assess the stability and pharmacokinetics of compounds from Syzygium campanulatum when enhanced by nano-liposomes.
• Conducted in vitro release assays to test stability.
• Evaluated oral bioavailability in Sprague-Dawley rats.
• Compared pharmacokinetic properties of extracts, isolated compounds, and nano-liposomes.
• NL-encapsulation significantly increased solubility and entrapment of key compounds.
• Oral bioavailability of 7-HMDF, HMF, and DMC was notably improved.
• Pharmacokinetic profiles showed better stability with nano-liposomes.