Vitamin D deficiency in polycystic ovary syndrome: a retrospective study integrating Mendelian randomization

Key Points

• This research aims to understand the role of vitamin D deficiency in the pathogenesis of polycystic ovary syndrome (PCOS) and to explore its causal relationship.
• Conducted a retrospective analysis of vitamin D levels in individuals with PCOS.
• Utilized Mendelian randomization to assess causal relationships between vitamin D deficiency and PCOS.
• Evaluated metabolic dysfunction as a contributing factor in PCOS.
• Found a significant association between vitamin D deficiency and metabolic dysfunction in PCOS.
• Mendelian randomization suggested a potential causal link between vitamin D levels and PCOS.
• Recommended further studies to explore the impact of vitamin D supplementation on clinical outcomes in PCOS.