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February 25, 2026

Comparison of the Efficacy of High-Flow Nasal Cannula and Bi-Level Positive Airway Pressure in Children with Asthma Exacerbation: A Systematic Review and Meta-Analysis

RCRuiduo ChengHenan University Huaihe Hospital and Huaihe Clinical Institute MZManru ZhangHenan University Huaihe Hospital and Huaihe Clinical Institute WZWang ZhangHenan University Huaihe Hospital and Huaihe Clinical Institute

Key Points

To compare the effectiveness of high-flow nasal cannula and bi-level positive airway pressure in treating asthma exacerbations in children.
Conducted a systematic review and meta-analysis of existing studies.
Included comparisons of ventilatory support methods.
Focused on studies reporting oxygenation outcomes.
Both HFNC and BiPAP provided adequate ventilatory support.
BiPAP showed a small increase in oxygen levels compared to HFNC.
Further research is needed to validate the findings.

Abstract

Both HFNC and BiPAP can provide adequate ventilatory support for children with asthma exacerbation. In the subset of studies reporting oxygenation outcomes (2-3 studies), BiPAP was associated with a small increase in PaO2/SaO2 compared with HFNC; this limited signal requires confirmation in larger, high-quality clinical trials.

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Cite This Study

Cheng et al. (Sun,) studied this question.

synapsesocial.com/papers/699e9166f5123be5ed04eea8 https://doi.org/https://doi.org/10.1080/02770903.2026.2633355

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