Long Non-Coding RNA H19 mediates STAT3 dependent activation of keratinocytes and fibroblasts in Systemic Sclerosis skin.

Key Points

• To investigate the role of lncRNA H19 in STAT3-dependent fibroblast and keratinocyte activation in systemic sclerosis skin.
• Analyzed the expressions of lncRNA H19 in skin samples from systemic sclerosis cases.
• Examined the effects of lncRNA H19 on fibroblast and keratinocyte activation through specific assays.
• Used molecular techniques to assess STAT3 activation in these cells.
• H19 expression was significantly elevated in systemic sclerosis skin samples.
• lncRNA H19 facilitated STAT3 activation in both fibroblasts and keratinocytes.
• Targeting lncRNA H19 may reduce fibrotic changes in skin associated with systemic sclerosis.