Novel chemistry and structural perspectives in vitamin B 12 -dependent radical SAM enzymes | Synapse
February 26, 2026Open Access
Novel chemistry and structural perspectives in vitamin B 12 -dependent radical SAM enzymes
Key Points
To explore the structural and mechanistic diversity of vitamin B12-dependent radical SAM enzymes and their evolutionary relationships.
Review of literature on vitamin B12-dependent radical SAM enzymes
Analysis of structural data and catalytic mechanisms
Comparative studies with other B12-dependent enzymes
Highlighted diverse structures and mechanisms of radical SAM enzymes
Identified evolutionary connections to other B12-dependent enzymes
Showed implications for understanding enzyme function and catalysis.
Abstract
This review highlights the structural and mechanistic diversity of B 12 -dependent radical SAM enzymes and their evolutionary links to other B 12 -dependent enzymes.