Restricted cubic spline analyses demonstrated a J-shaped association between achieved SBP and major adverse cardiovascular event irrespective of CVD history. Maintaining SBP within 110 to 140 mm Hg was similarly associated with lower cardiovascular risk in patients with and without CVD. Risk appeared lowest when SBP was between 120 and 130 mm Hg, while an SBP target <110 mm Hg may offer additional benefit among patients without CVD.
Lyu et al. (Tue,) studied this question.