This research aims to identify characteristics of very early-onset inflammatory bowel disease (VEO-IBD) linked to genetic factors.
Multicenter registry study conducted in Japan
Focused on patients presenting an IBD-U phenotype
Emphasized history of severe infections during infancy
Identified the need for prioritizing genetic analysis in specific VEO-IBD patients
Highlighted association with severe infections during early life
Abstract
Patients with VEO-IBD who present an IBD-U phenotype and have a history of severe infections during infancy should be prioritized for genetic analysis to investigate the possibility of monogenic IBD.