What question did this study set out to answer?

To develop a workflow that combines histology and molecular profiling for postmortem analysis of auditory and vestibular organs.

February 26, 2026Open Access

Integrated Histology and Molecular Profiling of Postmortem Human Auditory and Vestibular Organs via a Poly (Methyl Methacrylate)-Based Workflow

DBDavid BächingerUniversity of Zurich BPBrock PeytonMassachusetts Eye and Ear Infirmary JNJacqueline Neubauer

Key Points

To develop a workflow that combines histology and molecular profiling for postmortem analysis of auditory and vestibular organs.
Utilized a poly (methyl methacrylate)-based (rPMMA) workflow.
Conducted histomorphological examinations.
Performed advanced molecular analyses.
Reduced analysis time significantly compared to traditional methods.
Lowered overall costs for integrated studies.
Provided spatially resolved insights into pathologies affecting hearing and balance.

Abstract

This rPMMA-based workflow combines gold-standard histomorphology with full compatibility for advanced molecular analyses. With dramatically reduced time and cost, it offers a new benchmark for integrated, spatially resolved studies of human hearing and balance pathologies.

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