Molecular Mechanisms and Recent Advances in Targeted Protein Degradation

Key Points

• The aim is to explore the molecular mechanisms and advancements in targeted protein degradation technology.
• Classified molecular mechanisms of TPD into degrader-dependent tagging and proximity-induced degradation.
• Analyzed characteristics of bifunctional chimeras and molecular glues from a molecular design perspective.
• Reviewed biological pathways including the ubiquitin-proteasome system, endosomal-lysosomal pathway, and autophagy-lysosome pathway.
• Described significant clinical advances with PROTAC molecules like ARV-471 entering Phase III clinical trials.
• Highlighted innovations in technologies such as LYTAC and ATTEC for targeted protein degradation.