Switchable N–H vs C3–H Carboxylation of Indoles using Dual-Function Reagents | Synapse
February 26, 2026Open Access
Switchable N–H vs C3–H Carboxylation of Indoles using Dual-Function Reagents
Key Points
The research aims to explore the dual functionality of reagents in carboxylation reactions of indoles.
Examined CO2 transfer reactions using carboxylate salts
Altered reaction conditions to promote either N–H or C3–H carboxylation
Analyzed product outcomes based on the reaction conditions
Demonstrated successful N–H carboxylation under specific conditions
Achieved C3–H carboxylation by varying the reaction parameters
Highlighted the versatility of carboxylate salts in synthesis
Abstract
The carboxylation of indoles through a CO2 transfer reaction with carboxylate salts is described. By altering the reaction conditions either N–H or C3–H carboxylation can occur. The reaction is also...