This research aims to identify genes linked to Alzheimer's disease and their effects on brain regions.
Conducted neuroimaging phenotype-wide association study (pheWAS)
Analyzed gene regulation in relation to vulnerable brain areas
Developed a framework for further functional validation
Identified priority genes associated with Alzheimer's disease
Demonstrated a link between gene regulation and vulnerable brain regions
Proposed a mechanism for understanding disease processes
Abstract
Our findings prioritize AD genes whose regulation is associated with vulnerable brain regions, offering a potential mechanistic framework for downstream functional validation.