Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA-Seq Analysis.

Key Points

• This research aims to investigate the transcriptomic differences in dental pulp subpopulations in response to S. mutans exposure.
• Isolated dental pulp cells (DACs and DPCs) were mechanically separated.
• Bulk RNA sequencing (RNA-Seq) was conducted to analyze transcriptomic profiles.
• Comparison of responses between DACs and DPCs post S. mutans exposure was performed.
• DACs showed enhanced activation of immunomodulatory pathways.
• DPCs demonstrated significant markers for cellular stress responses.
• Distinct functional roles were suggested for DACs and DPCs in tissue defense and homeostasis.