Export Honey was known from the early decades as a medicinal agent. It contains substances that were shown to have protective and therapeutic effects. This study aimed to systematically review the evidence of the effect of natural raw honey use in treating variable skin conditions. Electronic databases were reviewed: PubMed, Scopus, and Science Direct. Relevant randomized controlled trials that were performed using human and animal subjects and published in the English language were utilized. Studies using natural pure honey as an intervention, without being mixed or combined with other substances, were revised. The effect of honey was compared to the effect of untreated control groups or those managed according to skin conditions’ standards of care. In total, 172 studies were identified, and 60 studies remained after initial screening through titles and abstracts. After full-text screening, 18 studies were utilized in this review. Studies examined the effect of honey on treating wounds, burns, or leishmaniasis. Considerable methodological variation existed regarding the tested outcome variables and the types and dosages of the honey applied as an intervention. Many studies demonstrated that the use of honey enhanced epithelization and reduced wound area effectively. Honey was a safe treatment for chronic wounds and diabetic ulcers. Japanese honey was paradoxically exerting negative effects in terms of wound healing. Systemic administration of honey (oral or intraperitoneal) produced prominent effects on the healing process when compared to the topical application of honey. Honey is a better treatment alternative than a placebo or silver sulphadiazine. However, further studies in this aspect are needed.
Al-Muhaisen et al. (Wed,) studied this question.
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