Exploration of the aromatic abietane diterpenoid scaffold in the development of ArnT-mediated colistin resistance inhibitors

Key Points

• The aim is to develop novel inhibitors targeting ArnT to combat colistin resistance in bacteria.
• Utilized a function-oriented synthesis (FOS) strategy.
• Developed abietane-based derivatives as potential inhibitors.
• Focused on ArnT-mediated resistance mechanisms.
• Successfully synthesized abietane derivatives.
• Demonstrated efficacy against ArnT in laboratory settings.
• Highlighted potential new pathways to address antibiotic resistance.