A suite of macrocyclic peptide inhibitors and substrate probes for arginine methyltransferases

Key Points

• The aim is to develop effective inhibitors and probes for arginine methyltransferases, which play crucial roles in various cellular processes.
• Synthesis of macrocyclic peptide inhibitors and substrate probes
• Assessment of inhibitory potency against arginine methyltransferases
• Evaluation of effects on chromatin structure and RNA processing
• Identified multiple potent macrocyclic peptide inhibitors for PRMTs
• Demonstrated effectiveness in modulating chromatin structure and RNA processing
• Highlighting potential implications for therapeutic strategies in cancer treatment