Combined experimental and DFT studies of amino acid adsorption on biomimetic apatite: application to serine

Key Points

• The study aims to explore how amino acids interact with biomimetic apatite, focusing on serine to improve understanding of biomolecule adsorption on bone minerals.
• Conducted experimental studies on amino acid adsorption using biomimetic apatite nanocrystals.
• Utilized density functional theory (DFT) calculations to model amino acid-biomimetic apatite interactions.
• Compared findings with traditional hydroxyapatite (HAP) to assess differences in adsorption behavior.
• Demonstrated effective adsorption of serine on biomimetic apatite.
• Outlined distinct interactions between amino acids and nanocrystals compared to stoichiometric HAP.
• Identified specific molecular pathways that facilitate amino acid binding.