What question did this study set out to answer?

To explore the overlap of ANCA associated vasculitis and Sjögren’s syndrome in an elderly male patient and review existing literature on this overlap.

February 27, 2026Frontiers in Medicine0 citationsOpen Access

The overlap of ANCA associated vasculitis with Sjögren’s syndrome in elderly male patient: a case report and literature review

MZMengting Zhu RZRuobing Zhu HZHaoran Zhu

Key Points

To explore the overlap of ANCA associated vasculitis and Sjögren’s syndrome in an elderly male patient and review existing literature on this overlap.
Case report of an elderly male patient with overlapping AAV and Sjögren’s syndrome.
Treatment included cyclophosphamide, glucocorticoids, hemodialysis, and rituximab.
Literature review identifying 49 similar cases of overlap syndrome.
Patient showed significant improvement post aggressive treatment.
Literature review identified 49 cases of AAV and Sjögren’s overlap syndrome.
Highlighted common characteristics and treatment outcomes in these cases.

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a rare disease characterized by inflammation of small vessels in various organs, usually affecting the kidneys, lungs, upper respiratory tract, skin, eyes, and peripheral nerves. The typical renal pathological manifestation is necrotizing crescentic glomerulonephritis. Sjögren’s syndrome is another relatively uncommon autoimmune disorder characterized by dry eyes and dry mouth. Here, we present a case of overlap syndrome involving AAV with SS in an elderly male patient who demonstrated significant improvement following aggressive treatment with cyclophosphamide, glucocorticoids, hemodialysis, and rituximab. In addition, we also found 49 cases of overlapping syndrome of ANCA combined with SS through literature review and summarized and analyzed them.

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