Higher Life's Essential 8 scores were associated with significantly lower odds of albuminuria, with the high CVH group showing a 74.7% lower odds of albuminuria compared to the low CVH group (OR 0.253).
Cross-Sectional (n=8,648)
Yes
Does higher adherence to Life's Essential 8 (LE8) reduce the odds of albuminuria in adults without chronic kidney disease?
Higher cardiovascular health scores, as measured by Life's Essential 8, are significantly associated with lower odds of albuminuria in a Northern Chinese population.
Effect estimate: OR 0.253 for high CVH vs low CVH; OR 0.552 for moderate CVH vs low CVH; 33% reduction in odds per 10-point increase in LE8 score (95% CI 95% CI 0.173-0.372 (high CVH vs low CVH); 0.388-0.786 (moderate CVH vs low CVH))
Absolute Event Rate: 5.6% vs 22.3%
p-value: p=<0.001 (high CVH vs low CVH); 0.001 (moderate CVH vs low CVH)
Albuminuria is strongly associated with the development and progression of cardiovascular disease. We aimed to investigate the association between Life’s Essential 8 (LE8) and albuminuria. The cross-sectional study enrolled 8,648 adults and excluded individuals with incomplete LE8 index data, missing serum creatinine or albumin/creatinine ratio data, and a diagnosis of chronic kidney disease. Albuminuria was defined as urinary albumin to creatinine ratio (uACR) ≥ 30 mg/g. According to the recommendation of the American Heart Association (AHA), the LE8 score was categorized into three groups: high cardiovascular health (CVH), medium CVH, and low CVH. To evaluate the relationship between LE8 and albuminuria, logistic regression and restricted cubic spline models were employed. Of the 8,648 participants, 949 (11.0%) had albuminuria. After adjusting for potential confounding factors, compared with the low CVH group, the moderate CVH group (odds ratio: 0.552; 95% confidence interval: 0.388 to 0.786; P = 0.001) and high CVH group (OR: 0.253; 95%CI: 0.173 to 0.372; P < 0.001) showed a significant lower odds of albuminuria, and a significant linear negative association between LE8 scores and uACR levels was observed, as well as a non-linear connection between LE8 score and albuminuria. The prevalence of albuminuria was greater among female individuals across all CVH groups compared to their male counterparts. The LE8 scores exhibited a negative correlation with albuminuria levels. Adhering to optimal cardiovascular health is associated with better kidney health.
Man et al. (Thu,) conducted a cross-sectional in Adults (≥18 years old) from a Northern Chinese general population without chronic kidney disease (n=8,648). Life's Essential 8 (LE8) cardiovascular health score vs. Low cardiovascular health group (LE8 score <50) compared to medium (50-79) and high (≥80) cardiovascular health groups was evaluated on Albuminuria defined as urinary albumin to creatinine ratio (uACR) ≥30 mg/g (OR 0.253 for high CVH vs low CVH; OR 0.552 for moderate CVH vs low CVH; 33% reduction in odds per 10-point increase in LE8 score, 95% CI 95% CI 0.173-0.372 (high CVH vs low CVH); 0.388-0.786 (moderate CVH vs low CVH), p=<0.001 (high CVH vs low CVH); 0.001 (moderate CVH vs low CVH)). Higher Life's Essential 8 scores were associated with significantly lower odds of albuminuria, with the high CVH group showing a 74.7% lower odds of albuminuria compared to the low CVH group (OR 0.253).