This study retrospectively evaluates the Predictive Bioharmonics (PB) dynamical-stability framework by applying its drift-based mathematical model to previously published quartile-level embryo development data (2,827 transferred embryos with documented t2–t4 timings and verified implantation outcomes). Individual embryo-level raw data were not analyzed; instead, reported quartile boundaries were used to compute representative drift ratios (r₂ = t₃/t₂ and r₃ = t₄/t₃). The objective was to determine whether published implantation-rate gradients align with PB-defined stability zones. Results demonstrate a monotonic alignment between computed drift ratios and published quartile-level implantation rates. These findings support the structural validity of the PB drift framework at a population level and justify prospective embryo-level clinical pilot evaluation. PB is a fully non-invasive mathematical framework that may, following prospective validation, be implemented using standard time-lapse morphokinetic timing data without additional hardware or procedural changes.
Tess Fries (Wed,) studied this question.