A case of primary cutaneous CD30－positive T－cell lymphoproliferative disorders requiring differentiation from Hodgkin lymphoma

Key Points

• To differentiate between primary cutaneous CD30-positive T-cell lymphoproliferative disorders and Hodgkin lymphoma based on clinical and pathological findings.
• Clinical examination revealing skin lesions and lymph node enlargement
• CT scan identifying lymphadenopathy
• Skin biopsy with histopathological examination
• PCR analysis for T-cell receptor gene rearrangement
• Skin biopsy revealed atypical cells and CD30 positivity in lesions
• PCR analysis indicated rearrangement in cutaneous lesions but not in other sample types
• Clinical suspicion of large cell transformation of mycosis fungoides was strong but inconclusive