What question did this study set out to answer?

The study aims to compare the efficacy of unspecific peroxygenases and Baeyer-Villiger monooxygenases in the sulfoxidation of heterobiaryl sulfides.

February 28, 2026Open Access

Biocatalytic synthesis of heterobiaryl sulfoxides: A comparative study between Baeyer-Villiger monooxygenases and unspecific peroxygenases

Q: What does this research mean for the field?

Unspecific peroxygenases (UPOs) are more effective than Baeyer-Villiger monooxygenases (BVMOs) for the biocatalytic sulfoxidation of heterobiaryl indole- and pyrrole-based sulfides. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Key Points

The study aims to compare the efficacy of unspecific peroxygenases and Baeyer-Villiger monooxygenases in the sulfoxidation of heterobiaryl sulfides.
Investigated sulfoxidation using unspecific peroxygenases and Baeyer-Villiger monooxygenases.
Tested various UPOs for their efficiency in converting sulfides.
Analyzed reaction products to assess enzyme performance.
Only specific unspecific peroxygenases showed effective conversion of heterobiaryl indole- and pyrrole-based sulfides.
Baeyer-Villiger monooxygenases displayed complementary but varied activity in the sulfoxidation process.

Abstract

The biocatalytic sulfoxidation of heterobiaryl indole-and pyrrole-based sulfides was investigated using unspecific peroxygenases (UPOs) and Baeyer-Villiger monooxygenases (BVMOs) as complementary oxidative biocatalysts. Among the UPOs tested, only the UPO from...

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Cite This Study

Vázquez-Domínguez et al. (Wed,) studied this question.

synapsesocial.com/papers/69a286eb0a974eb0d3c02359 https://doi.org/https://doi.org/10.1039/d6ob00171h

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