To develop a sustainable and efficient continuous-flow N-alkylation method for amines using a biphasic solvent system.
Developed a continuous-flow protocol
Used a biphasic solvent system
Applied green chemistry principles
Achieved efficient N-alkylation
Demonstrated reduced environmental impact
Highlighted simplicity and speed of the protocol
Abstract
The alkylation of the nitrogen atom is a key reaction class for the synthesis of building blocks, APIs and other bioactive compounds. Herein, we report a green N-alkylation methodology that...