Multilineage differentiation drives hamartoma formation in large-to-giant congenital melanocytic naevi: evidence for naevocyte multipotency

Key Points

• To explore the role of multilineage differentiation in the formation of hamartomas from large-to-giant congenital melanocytic naevi.
• Analyzed LGCMN cells for stemness and multipotency compared to SMCMNs.
• Examined the neuroactive ligand-receptor pathway's role in differentiating LGCMN cells.
• Utilized comparative differentiation assessments between LGCMN and SMCMN.
• LGCMNs exhibit significantly higher multipotency compared to SMCMNs.
• The neuroactive ligand-receptor pathway is implicated in driving LGCMN transdifferentiation.
• Findings suggest the potential for targeting differentiation pathways in therapeutic interventions.

Abstract