Repeated changes in chemotherapy including pazopanib led to long-term survival (200 months) in scalp angiosarcoma, with maintenance chemo significantly extending survival in 22 patients.
Does maintenance chemotherapy improve survival in patients with angiosarcoma?
24 patients with angiosarcoma treated at Iwate Medical University Dermatology Department between 2015 and 2025, including a detailed case report of a 42-year-old female with scalp angiosarcoma.
Maintenance chemotherapy
No maintenance chemotherapy
Survival timehard clinical
Maintenance chemotherapy significantly prolonged survival in a retrospective cohort of angiosarcoma patients, highlighted by a case of 200-month survival with sequential chemotherapy changes.
42歳,女性。右前頭部に20 mm大斑状型の血管肉腫が生じ,皮膚悪性腫瘍切除術,分層植皮術を行った。術後放射線療法80 Gy行い,ドセタキセルを1年8ヵ月,パクリタキセルを10年8ヵ月投与した後に,皮膚転移が生じた。エリブリンに変更後,投与31ヵ月で頭蓋骨転移が生じた。パゾパニブに変更し,初診より200ヵ月の長期生存が得られている。その症例を併せて,2015〜2025年に岩手医大皮膚科を受診した血管肉腫24症例をまとめ臨床的に検討した。生存もしくは死亡の転帰が不明である2例を除外し,22例で生存曲線を作成,維持化学療法を行った群で有意に生存期間の延長がみられた。
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Hirofumi Kamada
S. MIURA
Masazumi Onishi
Skin Cancer
Iwate Medical University
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Kamada et al. (Wed,) reported a other. Repeated changes in chemotherapy including pazopanib led to long-term survival (200 months) in scalp angiosarcoma, with maintenance chemo significantly extending survival in 22 patients.
www.synapsesocial.com/papers/69a287b00a974eb0d3c0399e — DOI: https://doi.org/10.5227/skincancer.40.194
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