Diagnosis of Granulomatosis with Polyangiitis in a Therapeutic Hospital

Granulomatosis with polyangiitis is a systemic autoimmune disease characterized by damage to small and medium-sized vessels, the formation of granulomas, and the formation of antibodies to neutrophil cytoplasm (ANCA). The prevalence of the disease is steadily increasing, affecting the working-age population. Late diagnosis and delayed treatment lead to rapid progression of the disease and death. The article presents a case of granulomatosis with polyangiitis with damage to the kidneys, upper respiratory tract, skin, and vessels, ANCA-positive in a 49-year-old man. The diagnosis was made in a timely manner by a general practitioner, which allowed for the initiation of pathogenetically based treatment with glucocorticosteroids and cyclophosphamide, with positive results.