Prediction of Chemotherapy Toxicity After Four Cycles of R-CHOP Treatment for Diffuse Large B-Cell Lymphoma: Effective Imaging Biomarkers of Body Composition.

Key Points

• This research aims to identify how body composition affects chemotherapy toxicity in patients undergoing R-CHOP treatment.
• Analyzed body composition metrics including baseline SM volume and its changes during treatment.
• Correlated these metrics with instances of grade 3/4 toxicity after four cycles of R-CHOP.
• Focused on overweight or obese populations.
• Lower baseline SM volume is linked to a higher risk of severe toxicity.
• Reductions in SM volume during treatment further increase toxicity risk, particularly in obese patients.