Impact of haemoglobin vesicles on pretransfusion testing and mitigation strategies.

Key Points

• The study aims to evaluate how haemoglobin vesicles affect pretransfusion testing methods and their implications for clinical use.
• Analyzed tube-based pretransfusion testing protocols.
• Investigated manual and automated washing procedures for blood samples treated with HbVs.
• Evaluated compatibility assessment accuracy with and without haemoglobin vesicles.
• Tube-based testing with HbVs requires specific washing procedures for accurate compatibility.
• Manual replacement and automated washing both show potential for mitigating compatibility issues.
• Further validation of these methods is essential for broader clinical application.