Effects of Bisphosphonates on Bone Micro-Architecture of Children With Duchenne Muscular Dystrophy: A Prospective Comparative Study. | Synapse
March 1, 2026
Effects of Bisphosphonates on Bone Micro-Architecture of Children With Duchenne Muscular Dystrophy: A Prospective Comparative Study.
Key Points
To assess the effects of bisphosphonates on bone micro-architecture in children with Duchenne muscular dystrophy.
Conducted a prospective comparative study
Administered zoledronic acid and alendronate to participants
Evaluated changes in bone micro-architecture
Improved bone micro-architecture observed
Increased trabecular bone score (TBS) noted
Enhanced aBMD (areal bone mineral density) recorded
Abstract
This relatively long-term study confirms that zoledronic acid and alendronate are beneficial to improve micro-architecture reflected by TBS and aBMD of children or adolescents with DMD.