SGLT2 Inhibitors Associated With Improved Kidney Function in Lithium-Treated Patients With Mood Disorders: A Real-World Historical Cohort Study.

Key Points

• This research examines the impact of SGLT2 inhibitors on kidney function in patients with mood disorders undergoing lithium therapy.
• Historical cohort study design
• Participants included patients receiving long-term lithium therapy
• Evaluation of eGFR (estimated Glomerular Filtration Rate) trajectory across treatment
• Significant improvement in eGFR trajectory observed with SGLT2 inhibitor treatment
• Findings suggest reduced risk of lithium-associated kidney dysfunction
• Need for future randomized controlled trials to confirm these results

Structured PICO

Abstract