Review on Nanoemulgel Used in the Treatment of Fungal Infection

Fungal infections affect many people around the world and are a major health concern. One reason they are difficult to treat is that several Fungi have developed resistance to commonly used antifungal medicines. because of this, many drugs do not work as well as they used to. Another problem is that most antifungal drugs cannot easily pass through the outer layer of the skin, so only a small amount reaches the infected area, many of these medicines also do not dissolve well in water, which reduces their effectiveness when applied on the skin. Nanoemulgel technology, which mixes very small nanoemulsion droplets with a gel base, has become a promising method to improve the delivery of antifungal drugs. The tiny size of the droplets helps increase drug solubility, allows more drug to be carried, and improves movement of the drug into deeper skin layers. The gel part makes the product easier to apply, helps it spread smoothly, and allows it to stay longer on the skin. This increases comfort for the patient and helps the drug work better at the infection site. nanoemulgels can greatly improve the action of lipophilic antifungal drugs such as clotrimazole, ketoconazole, luliconazole and fluconazole. These formulations can deliver the drug more effectively, improve treatment results, and reduce the need for frequent application.