MSC-small extracellular vesicles alleviated Th2-airway inflammation by regulating the metabolism of DCs in mice.

Key Points

• The aim is to understand how MSC-sEV influence DC metabolism to mitigate Th2 airway inflammation in mice.
• Administer MSC-small extracellular vesicles (sEV) to mice with Th2 airway inflammation.
• Assess metabolic state of dendritic cells (DCs) focusing on oxidative phosphorylation and glycolysis.
• Evaluate the impact on inflammatory responses initiated by DCs.
• MSC-sEV promoted oxidative phosphorylation in DCs over glycolysis.
• Reduced DC-mediated inflammatory responses were observed.
• Th2 lung inflammation was significantly attenuated in treated mice.