What does this research mean for the field?

Cardiac magnetic resonance (CMR) and genomics research data from international population studies can uncover novel gene-lifestyle-disease interactions and facilitate the discovery of new therapeutic targets and biomarkers. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To examine the role of cardiac magnetic resonance and genomic data in population studies, highlighting their implications for disease understanding.

March 1, 2026JACC. Cardiovascular imaging0 citationsOpen Access

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Systematic Review of International Population Studies With Cardiac Magnetic Resonance and Genomics Research Data (“Imagenomics”)

KHKerrick HesseWilliam Harvey Research Institute NAN AungSt Bartholomew's Hospital SPSteffen E. PetersenQueen Mary University of London

Key Points

To examine the role of cardiac magnetic resonance and genomic data in population studies, highlighting their implications for disease understanding.
Conducted a systematic review of international population studies involving CMR and genomics.
Identified 17 relevant biobanks through database searches.
Summarized the challenges and opportunities related to biobank data usage.
Approximately 1 million participants are included across the examined studies.
Over 180,000 participants have undergone or will undergo cardiac magnetic resonance imaging.
Emphasized the need for safeguarding participant confidentiality and promoting inclusivity in research.

Abstract

Epidemiological population studies may include cardiac magnetic resonance (CMR)-derived phenotyping and large-scale genotyping, providing unprecedented level of detail to investigate novel gene-lifestyle-disease interactions. The systematic review presents high-level summaries and critically appraises contemporary challenges and biobank opportunities. The authors identified 17 relevant biobanks by searching "CMR," "genome" and "population study" on MEDLINE, EMBASE, and Web of Science 2025. Collectively, studies recruited ∼1 million participants with stored blood samples for extensive genomic analyses, of whom >180,000 have or will undergo CMR. Use of expansive personal data must safeguard participant confidentiality, encourage technological standardization, and champion inclusivity and sustainability. Application of genotypic and imaging-derived phenotypic information will be readily translatable to clinical practice through investigation of, among others, new therapeutic targets and highly sensitive and specific biomarkers. Imaging biobanks are accessible to researchers by application. This systematic review should inspire greater use and cross-collaboration and facilitate powerful discoveries in more heterogeneous population samples.

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Systematic Review of International Population Studies With Cardiac Magnetic Resonance and Genomics Research Data (“Imagenomics”)

Key Points

Abstract

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