Beta-blocker use increased from 81.2% to 96.5% one year after CRT implantation, while diuretic use rose from 62.4% to 84.7%, with stable dosing.
Does pharmacological treatment change in heart failure patients during a 1-year follow-up after CRT implantation?
CRT implantation in heart failure patients is associated with an increase in the prescription rates of beta-blockers and diuretics, as well as an overall increase in the number of cardiovascular medications at 1-year follow-up.
Absolute Event Rate: 0% vs 0%
Background: Cardiac resynchronization therapy (CRT) is associated with improved morbidity and mortality in patients with chronic heart failure (HF). Optimal medical therapy also plays an important role for CHF patients prognosis and quality of life. Purpose: To evaluate pharmacological treatment changes of HF patients during 1-year follow-up of CRT. Methods:We evaluated 85 consecutive HF patients pharmacological treatment during 1-year follow-up of CRT. Medication consumption data were assessed before CRT, at the time of hospital discharge following CRT implantation and 1-year follow-up visit. Statistical analysis was performed using SPSS version 21.0. Results: Beta-blockers were used in 81.2% of patients before CRT, consumption increased after CRT implantation (96.5% at 1-year follow-up visit) (p <0.002). Angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) consumption and dose didn’t changed statistically significant during study. The average dose of spironolactone changed statistically significant comparing spironolactone dose before CRT with the discharge from the hospital period (p=0.02). The use of diuretics was significantly higher after CRT device implantation, compared with period before CRT from 62.4% to 84.7% - at discharge and at 1-year follow-up visit (p<0.001), but doses of torasemide hasn’t changed statistically significant, comparing the period before CRT with both, hospital discharge (p=0.5) and 1-year follow-up periods (p=0.8). Cardiovascular medications consumption was significantly lower before CRT 4.6±2.1, compared with discharge 5.6±1.8 (p<0.001) and follow-up 5.5±1.8 (p<0.001) periods. Conclusions: 1. Beta-blockers, ACEI and diuretics were the most frequently used medications. 2. Beta-blockers consumption increased after CRT implantation. 3. The use of diuretics was significantly higher after CRT device implantation, but average dose of the loop diuretic after CRT remained almost the same. 4. Ca
Laukaitienė et al. (Sat,) reported a other. Beta-blocker use increased from 81.2% to 96.5% one year after CRT implantation, while diuretic use rose from 62.4% to 84.7%, with stable dosing.
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