Early intravenous immunoglobulin treatment and physiotherapy in a 3-month-old with AFM led to MRI lesion resolution and motor improvement at 3 months.
Does intravenous immunoglobulin and physiotherapy improve clinical and radiological outcomes in an infant with acute flaccid myelitis?
Early identification and prompt treatment with intravenous immunoglobulin and physiotherapy may lead to clinical and radiological improvement in infants with acute flaccid myelitis.
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A bstract Acute flaccid myelitis (AFM) is a rare but serious neurological condition that primarily affects the gray matter of the spinal cord, leading to sudden onset of muscle weakness. AFM often follows a viral illness, especially respiratory infections, and has been associated with enteroviruses. A 3-month-old previously healthy baby presented with an acute onset of asymmetrical lower-limb paralysis following a brief upper respiratory viral illness. The lumbar puncture was normal, with a negative viral polymerase chain reaction result. Nerve conduction studies showed acute motor axonal neuropathy. The magnetic resonance imaging (MRI) was suggestive of a spinal cord gray matter lesion. The baby was treated with intravenous immunoglobulin and physiotherapy, and at the 3-month follow-up, resolution of spinal gray matter lesions on MRI, along with an improvement in power, has been documented. Early identification and prompt treatment of AFM in young infants have been highlighted.
Srinivasa et al. (Fri,) reported a other. Early intravenous immunoglobulin treatment and physiotherapy in a 3-month-old with AFM led to MRI lesion resolution and motor improvement at 3 months.