What question did this study set out to answer?

To evaluate the effectiveness and safety of dolutegravir + lamivudine compared to traditional three-drug regimens in clinical practice.

March 1, 20260 citations

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Comparative effectiveness of dolutegravir + lamivudine versus three-drug regimens in Swedish clinical practice: a nationwide study.

ESErik Sörstedt GNGeorge M. Nduva FMFredrik Månsson

Key Points

To evaluate the effectiveness and safety of dolutegravir + lamivudine compared to traditional three-drug regimens in clinical practice.
Analyzed a nationwide cohort of patients in Sweden
Compared rates of virologic failure and treatment resistance between DTG+3TC and three-drug regimens
Monitored long-term outcomes over a significant time period
Switching to DTG+3TC showed low rates of virologic failure
There was a low incidence of antiretroviral therapy resistance observed
Eligible individuals experienced no increased risk when switched to the new regimen

Abstract

In this long-term, real-world, national cohort, switching to DTG+3TC was associated with low rates of VF and antiretroviral therapy resistance, indicating that eligible individuals can be switched to DTG+3TC without increased risk of VF.

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Comparative effectiveness of dolutegravir + lamivudine versus three-drug regimens in Swedish clinical practice: a nationwide study.

Key Points

Abstract

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