A Self-Energized Photodynamic Therapy Agent Based on Persistent Luminescence Nanoparticles

Key Points

• The research aims to address key limitations of photodynamic therapy in cancer treatment through innovative nanoparticles.
• Developed self-energized persistent luminescence nanoparticles for PDT.
• Assessed stability and light penetration capabilities in tumor environments.
• Evaluated effectiveness in inducing tumor cell death under hypoxic conditions.
• Enhanced light penetration depth compared to traditional PDT methods.
• Improved stability of the photosensitizer in simulated tumor microenvironments.
• Increased tumor cell death observed under hypoxic conditions with the new nanoparticles.