Retinal microvascular dysfunction in mild cognitive impairment: Associations with cerebral small vessel disease, plasma biomarkers, and cognitive decline. | Synapse
Retinal microvascular dysfunction in mild cognitive impairment: Associations with cerebral small vessel disease, plasma biomarkers, and cognitive decline.
This research aims to explore the relationship between retinal microvascular dysfunction and cognitive decline in mild cognitive impairment (MCI).
Analyzed retinal microvascular health in individuals with mild cognitive impairment.
Assessed associations with indicators of cerebral small vessel disease and neurodegeneration.
Evaluated the role of plasma biomarkers in relation to cognitive status.
Retinal microvascular dysfunction was significantly associated with indicators of cerebral small vessel disease.
Plasma biomarkers correlated with the degree of cognitive decline observed in the participants.
Findings suggest retinal health may serve as a non-invasive biomarker for early detection of cognitive impairment.
Abstract
Retinal microvascular dysfunction in MCI reflects concurrent cerebral SVD and neurodegeneration, supporting its potential as a non-invasive biomarker for early cognitive decline.