Isotretinoin, a derivative of retinoid and the biologically active form of vitamin A, is the ideal drug for severe, moderate, and mild acne, especially resistant acne. Highly effective as it is, it has many possible side effects, which may significantly impact the quality of life of the patient. This case report describes a patient who, while being treated with isotretinoin for moderate to severe acne vulgaris, developed progressive conjunctivitis and facial dermatitis. While the acne lesions of the patient showed initial improvement, the patient developed worsening ocular irritation and facial erythema, which was very distressing. Discontinuation of isotretinoin led to gradual resolution of dermatitis and conjunctivitis. This report highlights the potential for serious ocular and dermatologic side effects of isotretinoin therapy, with a stressed need for early diagnosis, close monitoring, and early intervention to avoid long-term consequences. As these side effects are infrequent, further study on predictive risk factors and management is necessary to maximize the safety profile of isotretinoin in the treatment of acne.
Shah et al. (Tue,) studied this question.