The emergence of tomato virus infection in humans represents a novel and concerning development in the field of infectious diseases. Initially restricted to plants, this virus has shown potential cross-species transmission, raising significant public health concerns. The present review explores the clinical impacts, transmission dynamics, preventive measures, and pharmaceutical therapeutic potentials associated with emerging tomato virus infection. Clinical manifestations often include mild to moderate fever, skin rashes, fatigue, and respiratory symptoms, resembling common viral illnesses, which complicates early diagnosis. Transmission is believed to occur through direct contact with infected plant materials, contaminated food sources, or vector-mediated pathways. Preventive strategies emphasize hygiene practices, monitoring of agricultural produce, and early detection through molecular diagnostic tools. The review also highlights the potential role of antiviral and immunomodulatory pharmaceutical agents that may offer therapeutic benefits, based on similarities with other plant-origin viral infections. Furthermore, the necessity for interdisciplinary collaboration among virologists, clinicians, and pharmacologists is emphasised to develop effective management strategies. Overall, this review provides an integrated understanding of the human health risks posed by tomato virus infection and underscores the urgent need for research into safe, targeted pharmaceutical interventions.
1Suhasini G., 2Surender Reddy K. 3Madhulekha R., *4Ugandhar T. (Sun,) studied this question.