Conclusions: Exposure of rats of all age groups to sodium nitrite and tobacco smoke causes intensification of free radical oxidation processes in the rats' bodies, manifested by the occurrence of oxidative and nitrooxidative stress, activation of lipoperoxidation and oxidative modification of proteins, suppression of the antioxidant system, energy supply processes, formation of endogenous intoxication, and increased intensity of inflammatory processes in the body.The most pronounced metabolic changes with underlying nitrite-tobacco intoxication were evidenced in the immature rats that were proved by the experimental data. The identified violations lead to severe intoxication of the body, which requires the additional introduction of corrective factors.
Fedoniuk et al. (Thu,) studied this question.