Regenerative Effect of Injectable Collagen Loaded With Mesenchymal Stem Cell–Derived Extracellular Vesicles in a Collagenase-Induced Tendinopathy Rat Model

Key Points

• The aim is to investigate the regenerative effects of collagen combined with stem cell-derived extracellular vesicles in a rat model of tendinopathy.
• Injected collagen carriers loaded with extracellular vesicles into rats with induced tendinopathy.
• Assessed regenerative effects on tendon healing over a specific period.
• Utilized a collagenase-induced model to simulate tendinopathy in rats.
• Observed significant improvement in tendon healing compared to control groups.
• Found enhanced biological activity in the collagen-EV composite treatment.
• Indicated potential for clinical applications in treating tendinopathy.