What question did this study set out to answer?

This study aims to assess the antimicrobial activity of a polyherbal hydrogel against specific pathogens.

March 2, 20260 citationsOpen Access

In-Vitro & in-Silico Evaluation of Polyherbal Hydrogel for Antimicrobial Activity

SKSachin R. Kamble1, Padmaja S. Giram2*, Snehal S. Jogdand3, Prasad S. Menkudale4, Pratik D. Kadere5

Key Points

This study aims to assess the antimicrobial activity of a polyherbal hydrogel against specific pathogens.
Authenticated ethnomedicinal plants were screened for phytochemicals.
Extracts were added to hydrogels in concentrations of 0.1–0.5%.
Antimicrobial, antibiofilm, and antioxidant activities were evaluated.
Molecular docking was performed using AutoDock’s Vina.4.2.
The hydrogel inhibited growth with MIC values of 56.8 µg/ml for Candida albicans and 66.8 µg/ml for Pseudomonas aeruginosa.
It demonstrated 65–70% antibiofilm activity.
The formulation showed significant antioxidant potential.

Abstract

Background: Rising resistance to standard antimicrobials underscores the need for safer, natural options. Polyherbal formulations enhance efficacy through synergistic plant combinations. Aim: This study aimed to evaluate a polyherbal hydrogel and assess its antimicrobial activity against Candida albicans and Pseudomonas aeruginosa, supported by molecular docking. Methods: Selected ethnomedicinal plants were authenticated and screened for phytochemicals. Extracts (0.1–0.5%) were incorporated into hydrogels. Antimicrobial, antibiofilm, and antioxidant activities were evaluated. AutoDock’s Vina.4.2 was used for docking. Results: The hydrogel showed effective inhibition (MIC: 56.8 µg/ml, 66.8 µg/ml), 65–70% antibiofilm activity, and strong antioxidant potential. Conclusion: The formulation showed promising antimicrobial and antioxidant effects.

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