What does this research mean for the field?

Phosphorylated proteins IQGAP1 and VIM, along with kinases ERK and GSK3α, are implicated in the progression of liver cirrhosis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to investigate the phosphorylation patterns associated with liver cirrhosis progression.

March 3, 2026Open Access

Spatial phosphoproteomics reveals regional phosphorylation features in liver cirrhosis progression

Key Points

The aim is to investigate the phosphorylation patterns associated with liver cirrhosis progression.
Conducted KEGG pathway analysis on differentially expressed phosphoproteins (DEPPs) between groups.
Compared DEPPs between PH/NH and PII/PH stages of liver cirrhosis.
Identified candidate molecules for further validation, including specific kinases.
Significant enrichment of pathways related to ribosome and actin cytoskeleton found among upregulated DEPPs.
Alterations in spliceosome pathways observed with different regulation patterns in PH/NH and PII/PH comparisons.
Identified candidate proteins IQGAP1, VIM, and kinases ERK and GSK3α related to disease progression.

Abstract

KEGG analysis revealed significant enrichment of ribosome, actin cytoskeleton regulation, and focal adhesion pathways among the upregulated differentially expressed phosphoproteins (DEPPs) from the PH/NH and PII/PH comparisons, whereas spliceosome alterations were observed among upregulated DEPPs of PH/NH and downregulated DEPPs of PII/PH. This study has identified several candidate molecules awaiting further validation, including the phosphorylated proteins IQGAP1 and VIM, as well as the kinases ERK and GSK3α, which may be implicated in the progression of LC.

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Authors

Mengyao Wu

Anhui University of Science and Technology

Huihui Tao

Anhui University of Science and Technology

Huaizhou Chen

81th Hospital of PLA

Journals

Journal of Translational Medicine

Actions

Institutions

Xiamen University

Anhui University of Science and Technology

81th Hospital of PLA

References and Citations

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Building similarity graph...

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Spatial phosphoproteomics reveals regional phosphorylation features in liver cirrhosis progression

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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