What question did this study set out to answer?

The aim is to synthesize and evaluate the antiviral effects of tricyclic pyrrole derivatives against Zika virus.

March 3, 2026Open Access

Tricyclic Pyrrole-Based Compounds as Zika Virus Inhibitors

Key Points

The aim is to synthesize and evaluate the antiviral effects of tricyclic pyrrole derivatives against Zika virus.
Synthesis of 23 pyrrole-based tricyclic derivatives with bulky amine moieties.
Evaluation of antiviral activity against ZIKV and SARS-CoV.
Assessment of cytotoxicity and selectivity index for the most active compounds.
Compound 2g showed the best antiviral activity against ZIKV in Huh-7 cells with EC50 of 0.4 µM.
CC50 for compound 2g was 230.5 µM, resulting in a selectivity index of 501.
All three active compounds reduced ZIKV yield by impairing viral protein production.

Abstract

A small library of 23 pyrrole-based tricyclic derivatives bearing bulky amine moieties was synthesized, and all were evaluated for their antiviral activities against ZIKV and SARS-CoV. Three compounds, derivatives 2g, 2h and 2j, elicited interesting activity against ZIKV: compound 2g, containing a bornylamine residue, showed the best activity against Huh-7 cells with EC50 and CC50 values of 0.4 μM and 230.5 μM, respectively, and a Selectivity Index (SI) of 501. All three compounds reduce ZIKV yield primarily by impairing viral protein.

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Cite This Study

Murineddu et al. (Sat,) studied this question.

synapsesocial.com/papers/69a67ed1f353c071a6f0a4c9 https://doi.org/https://doi.org/10.3390/ijms27052306

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