March 3, 2026Open Access

Circulating B-cell activating factor in acute coronary syndromes – association with adverse outcomes and progression of heart failure

Key Points

BAFF may contribute to adverse outcomes after myocardial infarction, linking it to heart failure progression.
The findings suggest that increased levels of circulating BAFF in acute coronary syndromes can worsen prognosis and patient outcomes.

Structured PICO

Are circulating B-cell activating factor (BAFF) levels associated with adverse outcomes, development of MI, and progression of heart failure in patients with acute coronary syndromes?

Population

Patients with acute coronary syndromes

Intervention

Circulating B-cell activating factor (BAFF) levels (exposure)

Outcome

Adverse outcomes, progression of heart failure, development of myocardial infarction (MI), and post-MI remodeling

Circulating BAFF may play a pathophysiological role in the development of myocardial infarction and subsequent adverse remodeling in acute coronary syndromes.

Abstract

Our study supports a role for BAFF in the development of MI, potentially also in post-MI remodeling.

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Cite This Study

Ueland et al. (Sat,) studied this question.

synapsesocial.com/papers/69a759e1c6e9836116a1f430 https://doi.org/https://doi.org/10.1016/j.atherosclerosis.2026.120642

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