Synthesis and evaluation of 5-phenoxylmethyl-1,3,4-oxadiazol-2-ones/oxadiazole-2-thiones as potent urease inhibitors

Key Points

• Potent urease inhibitors were identified from synthesized compounds, showing promising activity against urease.
• The study evaluated various derivatives, with some compounds exhibiting inhibition rates above 80% in assays.
• Synthesis of 5-phenoxylmethyl-1,3,4-oxadiazol-2-ones and oxadiazole-2-thiones was conducted following standard chemical protocols.
• These findings support further exploration of these compounds for potential therapeutic applications.