Preparation of Fe2O3/GCN/ICG/DHA Nanocomplexes and Their Multifunctional Combined Antitumor Properties

Introduction: Malignant tumors seriously affect people’s normal lives, but the effective treatment of cancer needs to be further improved. Methods: In this study, we prepared nanocomposites with photothermal therapy (PTT)/photodynamic therapy (PDT)/chemodynamic therapy (CDT) properties named Fe 2 O 3 /GCN/ICG/DHA. Under high H 2 O 2 conditions, Fe 3+ is reduced to Fe 2+ and reacts with DHA to produce C-center free radicals, which kill tumor cells. In addition, ICG produced a warming effect and cytotoxic singlet oxygen with 808 nm laser irradiation. Results: The significant combined antitumor activity of Fe 2 O 3 /GCN/ICG/DHA, validated in vitro and in vivo, provides strong experimental support for advancing this transition metal iron-based nanocomplex towards tumor therapy applications. Discussion: It expands the potential applications of novel nanocomplex in the field of tumor therapy. Keywords: nanocomplexes, malignant tumors, chemodynamic therapy, photothermal therapy, photodynamic therapy